تعريف “فرط الحرارة الخبيث”

2011 ????? ??? ??????? ?????? ?????

??????? ??????? ????

KFAS

??? ??????? ?????? ????

????? ??? ??????? ?????? ?????? ??? ????? ? ??????? ?? ???? ??? ?????? ????? ???? pharmacogenetic ???? .

??? ??????? ???????????? ??????? ????? ??? ????? ?? ????????? ???????? ????? ?? ?????? ???????? ??????? sacroplasmic reticulum ??????? ????????? ??? ???? ??? ????? ????????? .

????? ????????? ???? ????? ?????? ????? ?????? ??????? ??????????? ?????? ?/ ?? ???????? ??????? .

?? ??? ????????? ???? ????? ??? ???? ????? ??? ??????? ???? ??????? ???? ??????? ?????? ???? ?? ??????? ????? ??????? .

??? ??? ????? Denborough ????? ???? ???? ????? ??????? ?? ???? ?? 10 ????? ?? ????? ????? ?????? ???? ??? ???????? ????? ??? ????? ?????? ???? ???? ?????? ???? ??????? ?? ???? ????? ?????? . ??? ??? ????? ??????? ?????? ????? ????? ????? ????????? ?? ?????? ?? ????? ??????? .

 

??? ??? ????? ?? ????? ??? ????? ??? ??????? hyperpyrexia ?? ??? ??????? ?????? . ???? ???? ?? ?? ?????? ?????? Isaacs and Barlow ????? ?????? ?? ??? ????? ?????? ????? ?????? ?? ??? ??????? ?????? ????? ???? ???? ????? ?????? ????? ????????? .

??? ????? ????? ??? ?? ?? ???? ????? Kalow and Britt ?????? ?????? ????????? ??????? ???????? ???????? ???? ????? ???? ????? ?? ????? ????? ????? ??? ?????? ??????????? chloroform. ????? ???? ?????? ?? ????? ??????? ??????? ?? ??????? ???? ??????? ?????? ????? ??????? ?????? ????? ???? ???????? ???? ????? ???? .

??? ????? ??????? ??? ???? ??????? Ellis et al. ????? ?????? ?? ?????????  halothane. ???? ???? ??????? ???? ????? ?? ????? ??? ?? ????????? dantrolene ???????? ???? ????? ????????? ???????? ?? ???????? ??????? ??????? . ??? ???? ?????? ?? ????? ??? ???????? ?? ????? .

?? ????? ?????? ??? ?????? ??????? ?? ??????? ???? ??????? ?????? ?? ???? ??????? ???????? ?????? ?????????? ????? ?????? ????? ??????? ??????????? ryanodine receptor (RYR1).

 

???? ??????? ???? ???? ??? ??????? ?????? ??? ????? ???? ??????? ???????????? ??????? ????? ?????? ?????????? ??? ???? ??? ?????? ????? ??????? ???? ????????? .

????? ???? ??? ??????? ?????? ?????? ?? ?????? ???????? ??????? ???? 1: 15.000 ???? ??????? ??????? ??????? ?????????? ? 1: 50.000 – 1: 150.000 ???? ??????? ??????? ???????? . ?????? ?????? ??? ????????? ??? ?????? ??? ????? ??? ???? ?? ???? ????? ????? 1 ?? 2000. ?????? ??? ??????? ?????? ???? ?????? ??? ?????? .

??? ?????? ??????? ??????? ??? ?????? ?????? ??????? ?????? ????? ????? ????? ??????? ???? ??? ??????? ??? ?????? ?????? ??????? ??? ????? . ??? ???? ??? ??????? ?????? ??? ??????? ??????? “???????” (?????? 10 – 2) ??? ?????? ???????? ??????? ??? ????? ?? ??????

?????? ?? ?????? ??? ??? ??????? ?????? ????? ?????? ??? ??? ??????? ??????? ? ??? ???? ???? ??????? 70%. ??? ?????? ??? ????????? ?????? ????? ??????????? dantrolene? ??????? ??????? ?? ?? ????? ?????? ?????? ??? ?????????? ????? ???????? ??????? ??? ? ??? ???? ??????? ???? ??? ?? 5% ?? ????? ???? ???? ???? ????? ???? ?????? .

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